This Week in Respiratory Health: AATD Protein Breakthrough, Tyvaso IPF Win, CT:VQ FDA Nod and More
From gene modulation in AATD to CT-based lung imaging and the first oral COVID-19 prophylaxis under FDA review, this week’s Respiratory Health Updates brings you the most critical developments transforming pulmonary medicine.
🧪 Key highlights:
🧬 Wave Life Sciences delivers first-ever evidence of endogenous AAT protein restoration in Pi*ZZ AATD patients; wild-type M-AAT increased to 7.2 µM, Z-AAT reduced by over 60 percent
🌬️📘 American Lung Association launches “Learning to Live with PF” — a national, nurse-guided program with mailed workbooks and caregiver networks
💊📉 Upstream Bio’s verekitug shows statistically significant 1.8-point polyp score drop (p less than 0.0001) in CRSwNP, with zero serious adverse events and potential for quarterly dosing
📉✅ Tyvaso by United Therapeutics improves lung function in IPF by 95.6 mL vs placebo in Phase 3, with broad subgroup benefits and FDA sNDA submission planned
🧪📉 SpliSense’s SPL84 inhaled ASO therapy improves ppFEV1 in up to 70 percent of cystic fibrosis patients, with no safety signals and expansion into IPF
💊🦠 Shionogi’s ensitrelvir under FDA review as first oral COVID-19 post-exposure prophylactic; Phase 3 data supports efficacy, decision expected by June 2026
🩺🎈 Airiver Medical receives FDA IDE for drug-coated balloon in airway stenosis; U.S. trial to enroll 200 patients testing paclitaxel + dilation
🖥️✅ 4DMedical’s CT:VQ™ secures FDA clearance as first CT-based VQ imaging platform
🚨 Whether you’re tracking biologics, pulmonary imaging, or FDA milestones, this roundup is your go-to source for the latest in respiratory innovation.
📢 Stay Ahead in Respiratory Research!
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