🔬🧬Oncology Updates: Keytruda Approvals, ADC Breakthroughs, and Solid Tumor Advances
From pediatric brain cancer gains to next-gen ADC designations and durable responses in solid tumors—this week’s oncology roundup brings essential updates transforming cancer therapy across multiple tumor types.
💡 Key Highlights This Week:
✅ Cellectar’s iopofosine doubles progression-free survival in pediatric glioma, with overall survival reaching nearly 15 months in some patients
✅ FDA approves Keytruda as the first PD-1 therapy for perioperative use in head and neck squamous cell carcinoma, reducing recurrence risk by 30 percent
🧪 Zepzelca and Tecentriq combo earns FDA Priority Review for first-line maintenance in small cell lung cancer with improved survival outcomes
🚀 Kelun-Biotech’s Sac-TMT plus tagitanlimab receives fifth Breakthrough Therapy Designation in China for lung cancer without genomic alterations
🔓 TuHURA’s IFx-2.0 plus Keytruda cleared to begin Phase 3 Merkel cell carcinoma trial under SPA agreement
🧬 Paxalisib and immunotherapy combo reduces EZH2 activity and re-sensitizes triple-negative breast cancer tumors; Phase 1b now recruiting in Australia
🌸 ENHERTU enters Phase 3 for HER2-positive endometrial cancer, targeting mismatch repair-proficient advanced or recurrent tumors
🧿 FDA endorses 900 micrograms per kilogram mitazalimab dose for Alligator’s Phase 3 pancreatic cancer trial; partnering discussions underway
💊 Zynyz plus chemotherapy delivers 9.3-month median PFS and a six-month OS benefit in anal cancer; FDA approval granted in May 2025
🎯 BI-1206 and Keytruda show 1 complete and 1 partial response in solid tumors, with 11 stable disease cases and subcutaneous formulation well-tolerated
🤝 Sanyou and Medicovestor announce ADC development partnership targeting cancer and autoimmune diseases; IND filing in pancreatic cancer advancing
🎯 Whether you’re tracking checkpoint inhibitors, novel ADC pipelines, or immunotherapy combinations—this update gives you the expert insights to stay informed and ahead.
📢 Stay Ahead in Oncology Research!
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