🔬🧬 Hematology Updates: Sanofi’s Myeloma Win, AI in Lymphoma, SCD Breakthrough and More
From FDA orphan designations to AI-driven treatment response in lymphoma and Canada’s latest CML approvals—this week’s hematology roundup captures the key global milestones transforming care in blood cancers and rare hematologic diseases.
đź’ˇ Key Highlights This Week:
✅ Sanofi’s SAR446523 receives FDA Orphan Drug Designation for relapsed/refractory multiple myeloma
âś… TIBSOVO plus azacitidine extends survival in IDH1-mutated AML to 29.3 months vs. 7.9 months in control arm
âś… Scemblix approved in Canada for first-line use in CML, achieving 68% MMR vs. 49% with standard TKIs
âś… AbbVie seeks FDA approval for fixed-duration oral combo of venetoclax + acalabrutinib in CLL with 35% risk reduction in progression
âś… Jaypirca outperforms Imbruvica in CLL head-to-head trial, meeting non-inferiority and trending toward superiority
✅ KYAN’s Optim.AI predicts drug response in lymphoma with 74.5% test accuracy and 3x PFS improvement
✅ BeOne’s BTK degrader BGB-16673 gets EMA PRIME designation for Waldenström’s; also holds FDA Fast Track
âś… Nuvisertib gains EMA Orphan Drug Designation for myelofibrosis with dual antitumor and antifibrotic activity
✅ Fulcrum’s pociredir delivers 8.6% mean HbF rise in sickle cell disease; 7 of 16 patients exceed 20% HbF
âś… Be Bio doses first patient in BE-101 trial, launching first engineered B cell therapy for hemophilia B
🎯 Whether you’re tracking first-in-class biologics, AI-driven clinical tools, or novel oral regimens in hematology—this episode delivers the essential updates shaping the next generation of treatment.
📢 Stay Ahead in Hematology Research!
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