🔬🩸 Hematology Updates: CAR-T in Myeloma, Columvi Approved in Canada, New F8 Mutation and More
From Australia’s first in vivo CAR-T dosing to Canada’s approval of its first bispecific for DLBCL, this week’s hematology roundup highlights powerful strides in cancer immunotherapy, rare disease care, and global access to life-changing treatments.
đź’ˇ Key Highlights This Week:
âś… Kelonia initiates Phase 1 inMMyCAR trial in multiple myeloma using KLN-1010, eliminating need for preconditioning chemotherapy
âś… Lisaftoclax enters global Phase III HR-MDS trial combining with azacitidine; first targeted frontline therapy in sight
🛡️ Faron’s bexmarilimab receives FDA clearance for registrational Phase 2/3 trial in HR-MDS targeting Clever-1
🇨🇦 Health Canada approves Columvi (glofitamab) for DLBCL; STARGLO study shows 41% reduced risk of death
🇨🇳 InnoCare begins mesutoclax registrational study in post-BTKi mantle cell lymphoma; BCL2-selective inhibition in focus
đź’Š EU approves BRUKINSA tablet for all indications; reduces daily dose to two tablets for better patient adherence
🔄 China greenlights AstraZeneca’s acquisition of FibroGen China; deal to close in Q3 2025
🇦🇬 Antigua set to open first-ever 24-hour sickle cell unit within two weeks at Old Holberton Hospital
🧬 Novel F8 gene mutation identified in 18-year-old; may reshape Hemophilia A treatment pathways
🇰🇬 World Federation of Hemophilia delivers over 5 million IUs of factor therapy in Kyrgyzstan; expands home treatment access for the first time
🎯 Whether you’re monitoring advances in myeloma, MDS, DLBCL, or Hemophilia A—this edition brings the most impactful hematology updates shaping clinical practice and global health equity.
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#Hematology #CAR_T #MultipleMyeloma #MyelodysplasticSyndrome #MDS #DLBCL #BCL2 #HRMDS #BispecificAntibodies #Hemophilia #SickleCell #BRUKINSA #FibroGen #AstraZeneca #GlobalHealth #BloodDisorders #LucidQuest #ClinicalTrials #HealthcareUpdates #BiotechNews