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EHA 2025 Preview: Key Hematology Highlights to Watch

EHA 2025_Preview_by_LucidQuest

EHA 2025_Preview_by_LucidQuest

EHA at a glance

Join LucidQuest for a concise EHA 2025 preview, focusing on must-see sessions and defining trends in hematology, including breakthrough therapies and the newest uses of AI in clinical practice.

๐Ÿ“…ย Build your schedule around the topics that interest you. ๐Ÿ“ฅ Download the EHA 2025_Preview_by_LucidQuest

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Key Topics From EHA 2025 Scientific Presentations

Leukemia

  • Cyclophosphamide delivers 73% ORR and superior MRD clearance over methotrexate in LGL.

  • GAIA/CLL13: BTKโ€“VEN (GIV) 5-year PFS 81% in fit CLL, confirming time-limited regimens.

  • Haplo vs mismatched-MUD transplants post-AML/ALL/MDS show equal 4-year OS โ‰ˆ 50%. โš”๏ธ

Myeloma

  • MIDAS multi-omics refines risk; hypoxia signature flags poor-prognosis MM.

  • Trispecific ISB 2001 and CELMoD combos yield deep responses in heavily pre-treated RRMM.

  • MRD-guided REMNANT intensifies frontline gains. ๐Ÿ”ฌ

Lymphoma

  • Acimtamig + Allo-NK posts high ORR in r/r cHL.

  • MRD negativity via PhasED-Seq predicts DLBCL survival.

  • Pelabresib + ruxolitinib improves MF fibrosis and anemia. ๐Ÿ›ก๏ธ

Transplant / GVHD

  • Target-dose ATG cuts CMV and speeds reconstitution.

  • Fecal microbiotherapy (MaaT013) rescues GI-aGVHD after ruxolitinib.

  • Axatilimab shows promise in chronic GVHD. ๐Ÿฅ

AML / MDS

  • Oral decitabine/cedazuridine + VEN matches IV outcomes.

  • Menin inhibitors (ziftomenib, revumenib) achieve high CRc/MRD-neg in NPM1/KMT2A AML.

  • DAC+HAAG beats 7+3 in adverse-risk AML for MRD and 2-year OS. โšก๏ธ

Autoimmune Cytopenias

  • Avatrombopag sustains platelets in pediatric ITP.

  • Sovleplenib (Syk) revives refractory AIHA.

  • Rilzabrutinib (BTK-i) boosts ITP responses. ๐ŸŒฑ

Bone Marrow Failure / PNH

  • Iptacopan, pegcetacoplan, crovalimab secure transfusion-free control.

  • Hetrombopag + CsA elevates NSAA response.

  • Luspatercept eases anemia in older NSAA. ๐Ÿ’‰

Classical Hodgkin Lymphoma (cHL)

  • PET-adapted protocols maintain PFS/OS with lower late toxicity.

  • Nivo-AVD delivers near-universal metabolic responses in frontline, while BBG salvage readies patients for transplant. ๐Ÿ”ฅ

Artificial Intelligence and Machine Learning at EHA 2025

AI_Diagnostics

  • Flow-cytometry and RNA-seq models classify AML, T-ALL, mastocytosis, neutropenia with high accuracy. ๐Ÿค–

Prognostic ML

  • Multivariate algorithms outperform IPSS-R in MDS and integrate genomics for AML/MPN risk. ๐Ÿ“Š

Digital Pathology

  • CIF mapping standardises fibrosis/blast counts in BMT slides across centres. ๐Ÿ–ฅ๏ธ

Therapy Predict

  • ML forecasts HMA response in MDS, CAR-T toxicity, and asciminib benefit in CML. ๐Ÿงฉ

Bleeding Risk AI

  • Models flag AML/ITP hemorrhage risk and evaluate VWD/AIHA drug efficacy. ๐Ÿฉบ

Explainable AI

  • SmartCytoFlow 2.0 delivers GPT-4o rationale-based outputs to boost clinician trust. ๐Ÿ’ก

Access Tech

  • Smartphone AI screens hemoglobinopathies in low-resource settings, widening early detection. ๐ŸŒ

๐Ÿ“…ย Build your schedule around the topics that interest you.

๐Ÿ“ฅ Download the EHA 2025_Preview_by_LucidQuest

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