EHA at a glance
Join LucidQuest for a concise EHA 2025 preview, focusing on must-see sessions and defining trends in hematology, including breakthrough therapies and the newest uses of AI in clinical practice.
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Key Topics From EHA 2025 Scientific Presentations
Leukemia
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Cyclophosphamide delivers 73% ORR and superior MRD clearance over methotrexate in LGL.
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GAIA/CLL13: BTK–VEN (GIV) 5-year PFS 81% in fit CLL, confirming time-limited regimens.
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Haplo vs mismatched-MUD transplants post-AML/ALL/MDS show equal 4-year OS ≈ 50%. ⚔️
Myeloma
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MIDAS multi-omics refines risk; hypoxia signature flags poor-prognosis MM.
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Trispecific ISB 2001 and CELMoD combos yield deep responses in heavily pre-treated RRMM.
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MRD-guided REMNANT intensifies frontline gains. 🔬
Lymphoma
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Acimtamig + Allo-NK posts high ORR in r/r cHL.
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MRD negativity via PhasED-Seq predicts DLBCL survival.
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Pelabresib + ruxolitinib improves MF fibrosis and anemia. 🛡️
Transplant / GVHD
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Target-dose ATG cuts CMV and speeds reconstitution.
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Fecal microbiotherapy (MaaT013) rescues GI-aGVHD after ruxolitinib.
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Axatilimab shows promise in chronic GVHD. 🏥
AML / MDS
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Oral decitabine/cedazuridine + VEN matches IV outcomes.
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Menin inhibitors (ziftomenib, revumenib) achieve high CRc/MRD-neg in NPM1/KMT2A AML.
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DAC+HAAG beats 7+3 in adverse-risk AML for MRD and 2-year OS. ⚡️
Autoimmune Cytopenias
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Avatrombopag sustains platelets in pediatric ITP.
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Sovleplenib (Syk) revives refractory AIHA.
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Rilzabrutinib (BTK-i) boosts ITP responses. 🌱
Bone Marrow Failure / PNH
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Iptacopan, pegcetacoplan, crovalimab secure transfusion-free control.
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Hetrombopag + CsA elevates NSAA response.
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Luspatercept eases anemia in older NSAA. 💉
Classical Hodgkin Lymphoma (cHL)
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PET-adapted protocols maintain PFS/OS with lower late toxicity.
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Nivo-AVD delivers near-universal metabolic responses in frontline, while BBG salvage readies patients for transplant. 🔥
Artificial Intelligence and Machine Learning at EHA 2025
AI_Diagnostics
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Flow-cytometry and RNA-seq models classify AML, T-ALL, mastocytosis, neutropenia with high accuracy. 🤖
Prognostic ML
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Multivariate algorithms outperform IPSS-R in MDS and integrate genomics for AML/MPN risk. 📊
Digital Pathology
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CIF mapping standardises fibrosis/blast counts in BMT slides across centres. 🖥️
Therapy Predict
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ML forecasts HMA response in MDS, CAR-T toxicity, and asciminib benefit in CML. 🧩
Bleeding Risk AI
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Models flag AML/ITP hemorrhage risk and evaluate VWD/AIHA drug efficacy. 🩺
Explainable AI
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SmartCytoFlow 2.0 delivers GPT-4o rationale-based outputs to boost clinician trust. 💡
Access Tech
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Smartphone AI screens hemoglobinopathies in low-resource settings, widening early detection. 🌍
📅 Build your schedule around the topics that interest you.
📥 Download the EHA 2025_Preview_by_LucidQuest
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