ECTRIMS 2025 at a glance
Ahead of ECTRIMS 2025 in Barcelona, see what to expect across MS epidemiology and risk, RIS and early-life factors, family planning, vascular and minority health, diagnostics/biomarkers, BTK inhibition/DMTs, and AI/ML—curated by LucidQuest.
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Key Topics From ECTRIMS 2025 Scientific Presentations
Epidemiology, Risk & Comorbidities
Vascular, early-life, pregnancy, and psychosocial factors will shape MS onset and progression—driving precision prevention.
Radiologically Isolated & Early-Life Risks
DACH RIS management varies; 127 neurologists differ on MRI/early DMT. Maternal age, BMI, and non-Nordic origin predict onset.
Family Planning, Fatigue & Sleep
OCR Pregnancy Registry (n=419) set to show MCM like controls. Trauma → fatigue via emotion dysregulation; poor sleep lowers early vitality.
Vascular, Pain & Minority Populations
MS-STAT2: vascular comorbidities worsen cognition; no simvastatin effect. CHIMES: OCR holds; diabetes ↑ infusion reactions; pain links brainstem/sensory.
Diagnostics & Biomarkers
Standardization to advance KFLC-enhanced CSF, RAM endpoints, and selective blood biomarkers—enabling earlier diagnosis and sensitive monitoring.
BTK Inhibition & DMTs
Tolebrutinib expected to lower CDP/PIRA, preserve HRQoL, with normal leukocytes/Ig/platelets. S1P/anti-CD20 durability and next-gen options mature.
Artificial Intelligence and Machine Learning at ECTRIMS 2025
- MRI Harmonization (U-Net3+): +19.4% INU, +21.6% CJV, +14.7% CNR vs N4 across 147 scans—cleaner multicenter analytics.
- T2-Lesion Segmentation: ICC 92–94%, voxel F1 0.73, ~10 s runtime; ~6% better than prior methods.
- Progression Prediction (n = 1,176): Random forest—2-year accuracy 83% (AUC 0.85); 5-year 74% (AUC 0.74).
- RMS → SPMS Forecasting: Conformal forests F1 0.83 on MSBase/Swedish registries—earlier, transparent identification.
- Remote EDSS via PROMs: MSE 0.42, R² 0.89; 90% within ±1 EDSS—telemedicine-ready.
📅 Build your schedule around the topics that interest you.
📥 Download the ECTRIMS 2025_Preview_by_LucidQuest
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