ACC at a glance
In the lead-up to ACC 2025, LucidQuest outlines the key trends shaping cardiology—from scientific advances to evolving diagnostics, treatment strategies, and AI applications.
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Key Topics From ACC 2025 Scientific Presentations
Ischemic Heart Diseases
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Complete revascularization in MVD lowers MACE/CV death vs. culprit-only PCI.
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DAPT reduces ischemic stroke but increases bleeding risk.
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Beta-blockers in MI with preserved EF may lack benefits. 🩸
Pulmonary Vascular Disease
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Mechanical thrombectomy tops thrombolysis in PE.
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Treprostinil improves #PAH exercise capacity. 🫁
Valvular Disease
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AS progresses faster in TTR-CA patients.
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DOACs best warfarin for R-MVD + AF.
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TAVR standardization lowers 1-year mortality. 💗🔎
Vascular Diseases
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Hypertension control remains poor.
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MANP aids resistant HTN (stronger in African Americans).
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Pollution + short LTL = worse atherosclerosis. 🌐🩺
Cardiac Arrhythmias
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Racial disparities in atrial flutter ablation outcomes.
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Class IC outperforms class III in #NICM.
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4.2% of young female athletes flagged by ECG. 🏃♀️⚡
Heart Failure & Cardiomyopathies
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ATTR-CM targeted therapies (vutrisiran, RNAi, SGLT2i) reduce mortality, enhance QoL, guiding new #HF management. 🏹💓
Cardiac Disease Prevention
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SGLT2i + colchicine cut MACE.
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Tirzepatide reduces CV risk.
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Nebivolol/valsartan synergy helps HTN. 🎯💡
Congenital Heart Disease
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Myosin inhibitors for HCM.
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Down syndrome patients show similar long-term survival.
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ASD closure fosters favorable remodeling. 🏥🔬
Special Topics
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Novel HF strategies, TAVI updates, and bridging inequities in cardiac care. 📈🩺
Artificial Intelligence and Machine Learning at ACC 2025
AI in Screening
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AI-ECG (AUROC ~0.94) flags HF, AF, HCM early. 🤖🔎
AI in Risk Stratification
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XGBoost & LGBM predict mortality in AMI-CS/post-PCI (AUC up to 0.955). ⚙️📊
AI in HFpEF
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EchoGo HF sees 50% risk for 27.9% preclinical patients. 🏹🌐
AI in Rare Disease
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Tools like SynapsisAI find 29 ATTR-CM in 1 week, specificity ~96%. 🏆🧪
AI in Valve Disease
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ML for TAVR sizing (AUC 0.85); DNN for RMV detection (AUC 0.877). ⛑️🔬
AI for Population Health
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Smartwatch AF detection = 1.6× MACE risk; AI-based CAC scoring finds unaddressed high-risk patients. 📲💗
AI in Pediatric and Global Health
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AI > standard ECG in WPW (AUROC 0.99); global RHD detection (AUC 0.89). 🌎🌱
AI Workflow
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ePRISM halves LOS post-PCI; NNM predicts same-day LAAC discharge (AUC 0.80). 🤝
Imaging AI
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ML multiparametric CMR (macro-AUC 0.90) for CAV staging; DTI-CMR + U-Net (Dice = 0.85) for arrhythmic imaging. 🏹💥
AI for Biomarker Personalization
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AI identifies tirzepatide responders; AI gait detects subclinical frailty. 🩺
Clinician Perceptions on AI
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64–75% lack ML knowledge, yet 75% see patient benefits—education gap remains. 📚⚖️
📅 Build your schedule around the topics that interest you.
📥 Download the ACC 2025_Preview_by_LucidQuest
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