This biweekly Cardiovascular Video Recap covers highlights regulatory approvals, reimbursement milestones, AI-enabled diagnostics, registry expansions, and systems-of-care analyses shaping cardiovascular practice across major markets.

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Top Stories Covered In This Video

Chapters

0:00 Introduction
0:08 AI-Based ECG Technology Enhances Aortic Stenosis Mortality Prediction
0:34 GAMEFILM Registry Expands to Include Retired NBA and NHL Athletes
1:02 Pert Teams Improve Outcomes but No Universal Formula for Success
1:28 FDA Approval of ENHANCE Heart Trial Boosts TransMedics Growth
1:52 AI-Powered ECG Improves Lifelong Heart Monitoring for Patients
2:19 Serbian Registry Reveals New Insights on Spontaneous Coronary Artery Dissection (SCAD)
2:40 Symplicity Spyral Renal Denervation System Gains Reimbursement Approval in Japan
3:02 Increase in Primary PCIs Shows No Reduction in Acute MI Mortality
3:29 How to reach us

Transcript

Welcome to the latest edition of Cardiovascular Updates, covering the latest breakthroughs. Brought to you by LucidQuest.

AI-based ECG technology may improve aortic stenosis mortality prediction. AccurKardia’s AI-powered ECG model, AK-AVS, can detect aortic stenosis up to 4.5 years before valve replacement is needed. This early detection allows for earlier diagnosis and better patient outcomes, offering an advantage over traditional imaging methods and improving risk assessment and intervention strategies for aortic stenosis.
Gamefilm Registry Expands to Include Retired NBA and NHL Athletes. HeartFlow has expanded its Gamefilm registry to include retired NBA and NHL athletes. This will help researchers better understand cardiovascular risks among former high-performance athletes. The addition of these athletes to the existing NFL cohort will broaden the scope of cardiovascular disease research, leading to more tailored care and improving early detection and preventive treatments for heart disease.
Perts improve outcomes, but “magic formula” does not exist. Cardiologist discussed the importance of Pulmonary Embolism Response Teams (PERT) in improving patient outcomes. However, there is no universal “formula” for success, and each institution needs to adapt its PERT model based on available resources. More research into adapting these models could lead to even better outcomes in the management of pulmonary embolism.
FDA approval of Enhance heart trial reshapes TransMedics growth story. TransMedics has received FDA approval for its OCS Enhance Heart trial. This trial aims to improve heart transplant technology by extending heart perfusion times, significantly enhancing organ preservation and expanding the adoption of TransMedics’ technology in clinical settings, reshaping the future of heart transplants.
AI-powered ECG could help patients requiring lifelong heart monitoring. Researchers at Mount Sinai have developed an AI tool that analyzes ECGs to prioritize MRI scans for patients with repaired Tetralogy of Fallot, a congenital heart defect. This AI-powered ECG technology could revolutionize lifelong heart health monitoring for patients with congenital heart disease, improving access and reducing healthcare costs.
Serbian registry offers new insight on spontaneous coronary artery dissection (Scad). A new study from the Serbian Scad registry reveals that stent implantation is often unnecessary for many Scad patients, as many cases resolve naturally. Conservative treatment strategies may prove more effective than stenting, potentially reducing unnecessary interventions and improving patient care.
Symplicity Spyral renal denervation system gains reimbursement approval in Japan. Medtronic’s Symplicity Spyral renal denervation system has received reimbursement approval in Japan for treating resistant hypertension. This approval will allow more patients to access a treatment that has been proven to reduce blood pressure over the long term, improving the management of resistant hypertension in Japan.
Rise in primary PCIs shows no reduction in acute MI mortality. A recent study analyzing primary PCI procedures in Europe shows no significant reduction in acute myocardial infarction (AMI) mortality rates, despite an increase in the number of PCI procedures. Variability in healthcare systems and patient complexity may explain why PCI procedures haven’t reduced mortality rates, suggesting the need for more individualized care.

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Why it matters

  • AI-ECG tools (AccurKardia, Mount Sinai) are being positioned as low-friction triage layers, but external validation and site-to-site performance remain central. [1], [5]
  • Registry expansions (Heartflow GAMEFILM, Serbian SCAD registry) show continued reliance on real-world cohorts to shape risk stratification and care pathways where RCTs are limited. [2], [6]
  • Systems-of-care models like PERT emphasize multidisciplinary throughput and follow-up, not just devices and drugs. [3]
  • Reimbursement decisions (Japan renal denervation) can accelerate adoption as much as clinical evidence, especially for procedure-based therapies. [7]
  • Europe-level outcomes analyses highlight that volume and access alone may not translate into population mortality gains without broader system factors (timeliness, complexity, operator workload). [8]

🗓️ Explore details and sources

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FAQ

What is AK-AVS, and what did AccurKardia claim it can do?

AK-AVS is AccurKardia’s AI-enabled ECG model for aortic stenosis. The source reports earlier detection signals and outcome prediction signals around TAVI care pathways (full endpoints and deployment details not specified here). [1]

What is Heartflow’s GAMEFILM registry studying, and who is now included?

GAMEFILM is a registry using CCTA plus Heartflow analysis to study CAD and plaque-related features in retired professional athletes. The expansion adds retired NBA and NHL athletes to the existing retired NFL cohort. [2]

What does a PERT change in pulmonary embolism care, per the LINC 2026 discussion?

The session described a multidisciplinary activation model (single call, core specialties, shared decisions) and reported improved outcomes, while emphasizing local customization rather than a universal template. [3]

What did Simply Wall St report about TransMedics and the ENHANCE Heart trial?

Simply Wall St reported FDA “full approval” for TransMedics’ next-generation OCS ENHANCE Heart trial, described as comparing OCS Heart with traditional cold storage in brain-death donors. [4]

How could the Mount Sinai AI-ECG tool affect follow-up for repaired Tetralogy of Fallot?

The source describes an AI model that uses standard ECG to estimate risk of ventricular remodeling, aiming to prioritize who needs cardiac MRI sooner, with performance differences across hospitals. [5]

What did the Serbian SCAD registry presentation suggest about stenting?

In this registry analysis, stent implantation was reported as an independent predictor of MACE, and the presenter stated stenting may not be beneficial in many SCAD patients (observational data, not randomized). [6]

Entities / Keywords

AccurKardia, AK-AVS, AI-ECG, aortic stenosis, TAVI

Heartflow, GAMEFILM registry, CCTA, plaque analysis, retired athletes (NFL, NBA, NHL)

PERT, Pulmonary Embolism Response Team, PE Tract (NIH), STRIKE-PE, PERT Consortium

TransMedics Group (TMDX), OCS Heart, ENHANCE Heart trial, organ care system

Mount Sinai, Tetralogy of Fallot (repaired), cardiac MRI, ventricular remodeling

SCAD (spontaneous coronary artery dissection), Serbian SCAD Registry, EAPCI Summit

Medtronic, Symplicity Spyral, renal denervation, resistant hypertension, MHLW (Japan)

Primary PCI, acute MI mortality, ESC Atlas, GDP per capita, operator workload

References

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