AHA at a glance

Get ready for AHA 2025 with LucidQuest’s concise preview. We spotlight must-see sessions and emerging themes in cardiovascular science and AI.

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Key Topics From Notable Presentations

Atrial Fibrillation & Arrhythmias

  • PFA beat thermal, delivering 12-month arrhythmia-free survival.
  • Elderly ≥80 showed increased stroke, heart failure, and mortality.
  • Academic centers had fewer redo ablations and AKI.

Lipid Management & Atherosclerosis

  • Obicetrapib cut LDL-C, ApoB, non-HDL-C, and raised HDL-C.
  • Recaticimab, a long-acting anti-PCSK9, reduced LDL-C.
  • ANGPTL3 inhibition, including evinacumab, lowered LDL-C and triglycerides.

Valvular & Structural Heart Disease

  • Post-SAVR rehabilitation reduced mortality and MACE; participation <50%.
  • Ataciguat slowed CAVS progression.
  • TAVR embolic protection did not reduce strokes.

Coronary Artery Disease & Ischemic Heart Disease

  • Vericiguat for ACS with LVEF <45% reduced events and improved QoL.
  • ICI rechallenge was viable.
  • P2Y12 monotherapy beat aspirin post-PCI.

Vascular & Peripheral Artery Disease

  • Smoking-related PAD DALYs declined in high-SDI, slowed in the U.S.
  • Ticagrelor + aspirin gave no benefit.
  • APOs increased PAD risk.

Heart Failure & Cardiomyopathies

  • Aficamten improved PROs and reduced oHCM severity.
  • Structured exercise improved capacity and remodeling without arrhythmias.
  • Mavacamten with standard therapy reduced hospitalizations and instability.

Hypertension & Renal/Cardiorenal Syndrome

  • Aldosterone synthase inhibitors, including lorundrostat, reduced BP with tolerability.
  • GMRx2 low-dose triple pill maintained 1-year control.
  • Amiloride matched spironolactone efficacy.

Metabolic, Obesity & Diabetes (Cardiometabolic Studies)

  • VK2735 (GIP/GLP-1) drove weight loss and improvements.
  • GLP-1 RAs reduced MACE.
  • Semaglutide 2.4 mg (SELECT) reduced MACE and HF.

Prevention, Lifestyle & Public Health

  • Psyllium improved glycemia in T2D.
  • Produce prescriptions lowered BP.
  • Medically tailored meals were cost-efficient.
  • Gamification increased activity.

Stroke & Cerebrovascular Disease

  • OAC monotherapy beat OAC + SAPT in bleeding and MI.
  • Thrombolysis worsened stroke outcomes.
  • EVT offered no benefit over BMT for DMVO.

Artificial Intelligence & Machine Learning at AHA 2025

AI-Enhanced ECG for Structural Heart Disease Detection

  • Wearable-integrated AI validated on 266,054 ECGs with 86% sensitivity and 87% specificity for SHD screening.

AI for Diastolic Dysfunction in Cardiomyopathies

  • AI-enabled ECG predicted diastolic dysfunction with 94% sensitivity in hypertrophic and amyloid cardiomyopathies.

AI in Hypertrophic Cardiomyopathy Screening

  • VIZ-HCM identified undiagnosed cases from EKGs, shortening timelines and improving SCD risk stratification.

AI-Based AF Ablation Guidance

  • coMAP predicted ablation success 82.4% vs 48.2%, outperforming conventional selection.

Real-Time AI Guidance for AF Ablation

  • coPilot guided catheters to termination sites with 85.7% accuracy, reducing ablation time.

 

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