🔬🩸 Hematology Updates: Myeloma Drug Approved, CAR-T Rules Relaxed, AI Hits 96% Accuracy and More
From the FDA’s accelerated approval of bispecific antibodies to gene therapy rollouts in Germany and universal artificial blood breakthroughs—this week’s hematology roundup delivers essential clinical and regulatory highlights transforming blood cancer care and beyond.
💡 Key Highlights This Week:
✅ FDA grants accelerated approval to Lynozyfic (linvoseltamab-gcpt) for relapsed/refractory multiple myeloma with 70% ORR and 45% CR
✅ CHMP endorses MRD negativity as a conditional approval endpoint in myeloma; aligns with FDA’s 12–0 ODAC vote
✅ FDA eliminates REMS for CD19 and BCMA CAR-T therapies, easing post-treatment burdens while maintaining long-term safety monitoring
✅ Duvelisib + Romidepsin combo yields 61% response, 47% CR in T-cell lymphomas; 82% response in nodal TFH subtype
✅ IL-18-secreting CAR-T therapy achieves over 80% response in B-cell lymphomas post-CD19 therapy; durable for over 2 years
✅ UF Scripps develops new ADC using tiancimycin to selectively kill aggressive lymphoma cells; moves to animal testing
🇩🇪 Germany administers its first HEMGENIX gene therapy for Hemophilia B; 94% off prophylaxis at 4 years
🇮🇳 India launches Phenome India Biobank to collect genomic and lifestyle data from 10,000+ participants for personalized medicine
🧃 Japanese researchers create universal, shelf-stable artificial blood compatible with all blood types; no serious side effects in early trials
📊 Ethiopia study identifies mortality predictors in febrile neutropenia, including ICU admission and prior neutropenic fever
🤖 AI achieves 96% accuracy across cancer types; CHIEF model enhances diagnostics and trial-matching in hematology
🎯 Whether you’re tracking CAR-T evolution, novel diagnostics, or the rise of AI in hematology—this episode delivers the latest insights fueling innovation in blood disease research.
📢 Stay Ahead in Hematology Research!
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